I am Dr.Md.Alauddin, is working as Assistant Professor, Department of Nutrition and Food Technology, Jashore University of Science and Technology, Jashore-7408, Bangladesh. My research objective is the development of functional food and evaluation its effect on metabolic syndrome with focus the cellular mechanism. My PhD awarded on “the effect of functional food component on metabolic syndrome in genetic animal model of life style-related disease from Laboratory of Nutrition ,Department of Science of Food Function and Health , Division of Bioscience and Biotechnology for Future Bioindustries ,Tohoku University, Japan, 2016. I am also interested on nutritional metabolites screening by High performance liquid chromatography (HPLC), LC-MS/MS, GC as well as fundamental bioinformatics, DNA sequence, PCR, RT-PCR, protein expression and characterization.

ACADEMIC CREDENTIALS

2016              PhD (Japan)

                      Bioscience and Biotechnology for Future Bioindustries

                      Tohoku University, Japan

 2004             Masters of Science (Thesis group)

                      Dept. of Biochemistry and Molecular Biology

                      University of Dhaka, Bangladesh.

 2003             Bachelor of Science (4 years Honors).

                      Dept. of Biochemistry and Molecular Biology

                      University of Dhaka, Bangladesh.

 1999             Higher school Certificate 

                      Group: Science

                      Jhenaidah City college

                      Board: Jessore.                                

 1997             Secondary School Certifícate  

                      Group: Science 

                      Bhaina shaheed mosharof Secondary school

                      Board: Jessore.   

 WORKING  EXPERIENCES

Postdoctoral researcher (Funded by World Bank), Academic-industry partnership:  

Department of Genetic Engineering & Biotechnology, University of Dhaka, (Jun 16, 2016 to December 2017). Genetic disorder inborn error of metabolism (IEM). Biosimilars/biologics development from yeast, bacteria and mammalian cells, bioprocess design to do industrial cell culture, media design, small to large scale protein purification using different chromatographic system, bio-analysis to do higher order protein characterization using LC/MS-MS, CZE, FACS, Biacore, immunogenicity study, Lateral flow kit development for disease diagnosis.

Research in Japan:

Division of Bioscience and Biotechnology for Future Bioindustries, Tohoku University, Japan (October 1, 2012 to March 25, 2016). Development of processed soymilk (PSM) as functional food from plant based soymilk by treatment with a commercially available proteinase to generate inhibitory peptides against the angiotensin I-converting enzyme (ACE). Novel ACE inhibitory peptide was identified from processed soymilk and investigated that processed soymilk containing tetra peptide FFYY effectively ameliorates hypertension on animal model of hypertensive rat SHR. The mechanism of how fermented rice bran (FRB) supplement suppress life style-related disease. FRB mitigates metabolic syndrome by regulating glucose and fat metabolism genes expression (G6C, PEPCK, ACaCa, GcK, L-PK, HMGCR, FASN, SCD1, CPT1, PRKAA1, AOX1 and VLCAD) and nuclear transcription factors (LXRα, SREBP-1c and ChREBPα mRNA). Furthermore, FRB increased serum adiponectin level and raised a strong correlation between fat mass and leptin level. Moreover, western blot analysis showed that FRB improved AMPK activation. These FRB can improve life style-related disease via ACE inhibition and improve adiponectin/AMPK signaling pathway in pre-diabetic condition.

Furthermore, Polyphenols (Melinjo resveratrol, dimer of resveratrol) isolated from plant seed and investigated its function as colorectal cancer remedy in Msh2 (DNA mismatch repair gene) knockout mice model. I developed Msh2^-/- mice model by genotyping and investigated melinjo resveratrol effectively extended the life span of Msh2 knockout mice which are prone to develop colon cancer compare to untreated mice.

Assistant Manager:

Quality Assurance Department, Renata Pharmaceuticals Ltd, Bangladesh ( 2011- September,2012).To assist with the new molecule launching, method validation, bioequivalence study, dossier preparation, ensuring quality of product by implementing WHO,ICH, MHRA guidelines, checking BMR, BPR, SOP and TP, operating the High performance liquid chromatography (Different HPLC; Agilent Dionex, waters and shimadzu), Gas chromatography (GC), Differential Scanning calorimeter (DSC), Atomic absorption Spectroscopy(AS). Partially involvement of bioequivalence study using LC-MS/MS. Leading method validation team.

 Sr.Officer PD:

Product Development Department, Renata Pharmacuticals Ltd, Bangladesh (2009 - 2010).To assist with the analysis of PD pilot batch, stability analysis and shelf life extension analysis, in process and finished product analysis, SOP preparation (40 SOP preparation), cleaning validation of production area. Familiar with USP, BP and EP analytical method.

 Quality control officer:

Quality Assurance Department, Renata Pharmacuticals Ltd, Bangladesh (April 2007 - 2008).To assist with the sampling and analysis of raw material and impurities profile, in process and finished product analysis.